The birth of the Global Fund in 2001 set in motion collaborations that have contributed to a global reduction in deaths across three diseases –HIV/AIDS by 61%, Tuberculosis by 25% and Malaria by 46%. As one of the players in this effective partnership, Uganda both contributes to and implements the Global Fund programmes. This partnership has made a significant contribution towards lowering the country’s disease burden of HIV/AIDS, Malaria and Tuberculosis. The partnership has also contributed towards building resilient and sustainable systems for Health. The Global Fund has disbursed over USD $1,624, 599, 234 to Uganda during the 20-year period. The Funds Coordination Unit of the Global Fund Grants supports the Ministry of Finance, Planning and Economic Development (MoFPED) as the Public Sector Principal Recipient (PR) to ensure effective and efficient use of the Global Fund resources.