The Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) today launched the Investment Case for its Eighth Replenishment during a global virtual event emphasizing strong collaboration with global donors and partners in an effort to accelerate progress toward ending the three diseases and improving global health security.
The Investment Case outlines how a fully funded Global Fund could save an additional 23 million lives between 2027 and 2029, reduce mortality from these diseases by 64% compared to 2023 levels and build stronger health and community systems to fight new outbreaks and pandemics.
“We stand at a critical moment in the fight against HIV, TB and malaria,” said Peter Sands, Executive Director of the Global Fund. “Without sustained investment, the remarkable progress this partnership has made to date is at risk. A US$18 billion investment will prevent 400 million new infections and save 23 million lives by 2029. The Global Fund’s unique partnership – combining local leadership with global expertise – has already reduced combined mortality from these diseases by 63%. Investing now strengthens global health defenses, ensuring outbreaks are contained before they spread. It’s not just about health –it’s about global security, stability and economic resilience.”
Today all partners who work to save lives and improve health in low- and middle-income countries are facing unprecedented financial constraints, putting the incredible progress in global health to date in jeopardy. Sustained investment and collective action are critical – not only to preserve past achievements, but also to finish the job and secure a healthier, disease-free future for all.
An historic opportunity for global health
“The impact of a fully funded Global Fund goes far beyond saving lives – it’s a game-changer for nations and communities,” Sands emphasized. “For every dollar invested, we expect a return of US$19 in health and economic benefits, amounting to an extraordinary US$323 billion over the next three years.”
The Global Fund partnership promotes sustainability by helping countries scale new technologies and service delivery. It also works to catalyze more efficient use of domestic financing and supports long-term planning so that countries can gradually take full ownership of their national health responses.
Lady Roslyn Morauta, Chair of the Global Fund Board, reinforced the power of collective action: “What once seemed insurmountable has become one of the greatest health success stories of our time. By coming together, we can turn this opportunity into a lasting legacy for healthier, stronger communities.”
The Global Fund is deeply committed to the mission of ending AIDS, TB and malaria. Recent innovations have put the possibility of ending AIDS by 2030 within reach if the partnership can expand access to HIV treatment and scale innovative prevention tools to protect people at high risk of contracting the virus.
Bience Gawanas, Vice-Chair of the Global Fund Board, highlighted the importance of equity: “This is not just about fighting disease; it’s about ensuring the most vulnerable populations receive the care they need. Our focus on sustainability and country-led solutions is critical to achieving long-term impact.”
Proven results and future commitments
The Global Fund partnership’s work has yielded extraordinary health improvements. In Zambia, for instance, life expectancy soared from 43 years in 2002 to 58 years in 2021, with over two-thirds of this increase attributed to reductions in deaths from AIDS, TB and malaria.
Despite challenges posed by COVID-19, economic instability, conflict and climate change, the fight against these diseases continues. The world is at a pivotal moment: Achieving Sustainable Development Goal (SDG) 3 – ending AIDS, TB and malaria as public health threats – is within reach, but only with sustained investment and innovation.
Beyond disease prevention, this funding will strengthen global health security, with about one-third of it reinforcing critical health infrastructure, including human resources, laboratories, disease surveillance and health information systems. These investments will fortify national health and community systems, ensuring resilience against future pandemics and health emergencies.
The time to act is now
The Global Fund calls on governments, civil society and the private sector to unite in this urgent effort. The time to act is now. Together, we can change the trajectory of global health, save millions of lives and create a healthier, safer and fairer world for all.
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